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Reasons for Premature Ovarian Failure

Premature ovarian failure commonly called as primary ovarian insufficiency is a condition when your ovaries that is responsible to store and release eggs stops functioning before 40 years of age. Premature ovarian failure in most cases results in less quantity of egg production and in few rare cases eggs will never be produced and can lead to infertility in women.

In case of premature ovarian failure, normal amounts of hormones are not produced. Estrogen commonly called as female hormone plays an important role in fertility. Lack of estrogen production can lead to infertility and also inhibit egg production and release.

Restoring estrogen level in your body can help you in avoiding complications caused due to premature ovarian failure. The common complication seen due to premature ovarian failure is osteoporosis. Osteoporosis is caused due to low levels of estrogen in your body.

Premature Ovarian Failure Symptoms

The signs and symptoms of premature ovarian failure are similar to menopause or estrogen deficiency. The common symptoms include:

  • Irregular periods or amenorrhea
  • Hot flashes
  • Night sweats
  • Vaginal dryness
  • Difficulty in conceiving
  • Difficulty in concentration
  • Decreased sexual desire

Premature Ovarian Failure Causes

During normal conditions, pituitary gland releases certain hormones during menstrual cycle which can cause the eggs containing follicles to start maturing. Generally one or two sacs that are filled with fluid reach maturity every month. The eggs are released only when the follicle becomes mature and opens up. The mature egg enters the fallopian tube to get fertilized by a sperm cell that can result in pregnancy.

There are several factors that are responsible for premature ovarian failure.

The common factors that can cause loss of eggs or oocytes resulting in premature ovarian failure include:

1.  Chromosomal Defect

Genetic disorders are mainly associated with premature ovarian failure. The common genetic disorders include mosaic Turner’s syndrome. In mosaic Turner’s syndrome you will have only one normal X chromosome and an altered second X chromosome. The other genetic disorder is fragile X syndrome – in which the X chromosomes are fragile and breaks easily.

2.  Toxins

Toxin induced ovarian failure is common in cases when you are exposed to radiation therapy or chemotherapy while undergoing a cancer treatment. Chemotherapy and radiation therapy can damage the genetic material present in your cells. Toxins also get accumulated in your body through cigarette smoking, chemical and certain pesticides that can also result in premature ovarian failure.

3.  Autoimmune Diseases

Autoimmune diseases results in the production of certain antibodies in your body. The antibodies produced in your body during auto immune diseases acts against your ovarian tissues and harm the egg containing follicles present in your ovaries. The egg gets damaged due to the production of antibodies produced in your body.

4.  Other Unknown Factors

In few rare cases, premature ovarian failure is caused due to certain unknown factors that can’t be diagnosed with the basic tests. Your gynaecologist might ask for certain other test to determine the factors that can lead to premature ovarian failure.

If you experience any symptoms related to premature ovarian failure, then immediately consult the best gynecologist in London, Mrs. Sarah Hussain for quick suggestions and better results.